Respiratory Microbiome in COPD and Associated Inmune Response.

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Unknown

Conditions: Pulmonary Disease (COPD), Chronic Obstructive

Study type: Observational

Funder types: Other

Identifiers

NCT03321708

IIBSP-MIC-2015-57

Details and patient eligibility

About

Hypothesis:

COPD patients with frequent exacerbations have different pulmonary and systemic immune response than COPD patients without frequent exacerbations and this is related to their microbiome.

Full description

The objective of this project is to determine the pulmonary microbiome and its relationship with the pulmonary and systemic inmune response in COPD patients with frequent (FE) and non frequent exacerbations (NE).

1. The pulmonary immune response.

   -The role of mucins, antimicrobial peptides (AMPs), Matrix metalloproteinases (MMPs) and Toll-like receptors (TLRs) as lung defense mechanisms and their possible relationship with the microbiome in COPD and FE patients.

2. The systemic immune response. -The pulmonary and blood inflammatory response and circulating bacterial products as markers of the systemic immune response.

Enrollment: 50 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Diagnosis of COPD according to national and international guidelines.
2. Clinical stability (8 previous weeks).
3. Signature of informed consent.

Exclusion criteria

1. Antibiotic treatment the previous 8 weeks.
2. Other lung diseases.
3. Active neoplasic disease.
4. Terminal concomitant disease.