Respiratory Muscle Fatigue at Different Breathing Modes

Aalborg University

Status

Unknown

Conditions

Healthy

Treatments

Other: Square wave breathing

Study type

Interventional

Funder types

Other

Identifiers

NCT05393115

Eso_pres_fatigue

Details and patient eligibility

About

The study aims at investigating if time to respiratory muscle fatigue and metabolism are influenced by the pressure wave form mode applied during resistive breathing.

Full description

In healthy subjects fitted with a nasogastric double balloon catheter and breathing at a resistance, the investigators will measure time to failure, Borg ratings, VO2, VCO2, flow, esophageal-, gastric- and airway-pressure. This will be done during breathing at either a square wave or triangle wave pressure waveform, in random order and trials separated by >two days. Further respiratory muscle fatigue will be investigated pre and post intervention by maximal esophageal pressure generation (voluntary and with cervical magnetic stimulation).

Enrollment

12 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men or women
Age ≥18 and ≤60 years
BMI ≥ 20 and ≤30

Exclusion criteria

Drug addiction defined as the use of cannabis, opioids or other drugs
Previous and present neurologic (e.g. ataxia), musculoskeletal (e.g. muscular dystrophy) or mental illnesses (e.g. schizophrenia)
History of mechanical ventilation, COVID-19 with respiratory complications, lung cancer
Part of lung resected
Presence of dyspepsia/heart-burn/abdominal pain
Presence of esophageal varices
Presence of liver disease
Presence of esophageal hernia
Pregnancy
Failure to comply with transcranial magnetic stimulation adult safety screen
History of epilepsy, metal implants in head or jaw
Acute or chronic lung diseases, e.g. asthma, COPD, bronchitis etc.
Lack of ability to cooperate