Respiratory Muscle Training in CF Patients (MUCOMUREE)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Respiratory Muscles; Cystic Fibrosis

Treatments: Other: Endurance respiratory muscle training; Other: Resistance inspiratory muscle training

Study type: Interventional

Funder types: Other

Identifiers

NCT03190031

2016-A01652-49

Details and patient eligibility

About

The present study aims at evaluating the effect of respiratory muscle training in adult patients with cystic fibrosis on lung function, exercise performance and quality of life.

Enrollment: 38 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a clinical diagnosis of cystic fibrosis
• Patients in steady state

Exclusion criteria

• Patients during exacerbation
• Patients treated by oral corticotherapy (>0.5 mg/kg/j during >7 days) during the past 2 months
• Pregnant patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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38 participants in 2 patient groups

Endurance respiratory muscle training

Experimental group

Description:

The intervention consists in performing isocapnic hyperpnea at 70-80% of maximal voluntary ventilation for 20 min, 5 times a week, for 8 weeks

Treatment:

Other: Endurance respiratory muscle training

Resistance inspiratory muscle training

Active Comparator group

Description:

The intervention consists in performing inspiratory resistive breathing at 70-80% of maximal inspiratory pressure for 20 min, 5 times a week, for 8 weeks

Treatment:

Other: Resistance inspiratory muscle training