Respiratory Pattern During Neurally Adjusted Ventilator Assist (NAVA) in Preterm Infants

Inha University Hospital

Status: Completed

Conditions: Respiratory Distress Syndrome In Premature Infants; Preterm Infants

Treatments: Device: Increasing and decreasing NAVA levels with 10-min intervals

Study type: Interventional

Funder types: Other

Identifiers

NCT02770976

NAVA-03-INV

Details and patient eligibility

About

This study is to investigate the effect of a wide range of assistance levels on respiratory pattern, breathing variability including tidal volume and peak inspiratory pressure during neurally adjusted ventilatory assist (NAVA) in preterm infants. The investigators also aim to explore whether the effects of NAVA on the electrical activity of diaphragm (Edi) signal amplitude, work of breathing and comfort of preterm infants.

Enrollment: 14 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• preterm infants born before 36 weeks of gestational age
• who received mechanical ventilatory care through the endotracheal tube at least 24 hours for respiratory distress
• no use of anesthetics or analgetics

Exclusion criteria

• with major congenital anomalies (facial, gastrointestinal tract, cardiac, etc)
• with phrenic nerve palsy or injuries

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

NAVA

Experimental group

Description:

Seven increasing and decreasing NAVA levels (0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 3.5, 3.0, 2.5, 2.0, 1.5, 1.0 and 0.5 cmH2O/uV) will applied to 20 preterm infants each for 10 minutes.

Treatment:

Device: Increasing and decreasing NAVA levels with 10-min intervals