Respiratory Physiology Under High Flow Therapy

I

Institut für Pneumologie Hagen Ambrock eV

Status

Completed

Conditions

Chronic Obstructive Pulmonary Disease

Treatments

Procedure: High flow therapy

Study type

Interventional

Funder types

Industry

Identifiers

NCT01509703
Trachea 2.0

Details and patient eligibility

About

The aim of this study is to gain knowledge about effects of high flow transnasal insufflation on various breathing parameters like intratracheal pressure conditions, CO2 elimination, breathing frequency and tidal volume.

Full description

Ten patients, who are supplied with a tracheostomy stent (placeholder) for reinsertions after long term ventilation will be treated for a short time during the day with the nasal high flow system AIRVO at different flow rates (15, 30, 45L/min) to estimate possible long term implications of high flow treatment. Respiration is measured by impedance plethysmography with a calibrated belt system (Respitrace, VIASYS). Pressure and end tidal CO2 concentration is measured inside of the placeholder. The order of the high flow rates (15, 30, 45L/min) is randomized; each flow rate is measured for 15 minutes. A wash out time of ten minutes is planned after each phase. In this time the patient breathes his individual oxygen flow rate with attention to the oxygen saturation, which should not exceed 96%. Transcutaneous PCO2 and SpO2 is monitored with TOSCA during the study.

Enrollment

10 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients in a stable weaning phase after long term ventilation
  • Patients supplied with tracheostomy stent (placeholder)
  • Patients in stable respiratory situation

Exclusion criteria

  • Incapable of giving consent
  • Any other severe or acute physical illness which requires intensive medical care

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

High flow therapy
Experimental group
Treatment:
Procedure: High flow therapy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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