Respiratory Rehabilitation and Sleep Quality in COPD Patients (REARSOM/BPCO)

University Hospital, Rouen

Status

Not yet enrolling

Conditions

COPD (Chronic Obstructive Pulmonary Disease)

Treatments

Procedure: rehabilitation

Study type

Interventional

Funder types

Other

Identifiers

NCT06677268

2022/0347/HP

Details and patient eligibility

About

COPD affects 5 to 8% of the population in France. The disease consists of inflammation of the large and small airways causing permanent obstruction of the airways and symptoms such as dyspnea, cough and sputum that worsens over time.

Among all COPD patients, 40% complain of sleep disorders. Polysomnography data showed a prolongation of sleep onset latency and a decrease in deep sleep, correlated with the severity of daytime hypoxemia. Conversely, poor sleep quality leads to an increase in dyspnea, altered quality of life and increased occurrence of COPD exacerbations.

Respiratory rehabilitation has demonstrated significant benefits on exercise capacity, dyspnea, COPD exacerbations and quality of life. To the investigators' knowledge, a few studies have investigated the relationship between physical activity and sleep quality using polysomnography in this population. Thus, the aim of the study is to evaluate the benefits of respiratory rehabilitation on sleep architecture in patients with COPD. Investigators' hypothesis is that a respiratory rehabilitation program would improve the quality of sleep measured by polysomnography. Therefore, patient with COPD and no exacerbation in the previous year will be randomly assigned to the interventional group who perform the rehabilitation program or to the control group who will not perform the program. The primary endpoint is the sleep quality estimated by total sleep time as measured by the mean of 2 independent polysomnography readings, at baseline and after the RR program in the interventional group and after 2 months of usual care in the control group.

Enrollment

90 estimated patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female ≥ age 50
COPD defined according to the GOLD 2022 criteria, clinically stable (without exacerbation for at least 4 weeks), with indication for respiratory rehabilitation
Absence of respiratory rehabilitation in the past 12 months
Patient affiliated to the social security system
For women of childbearing potential who have been on effective contraception (estrogen-progestogen or intrauterine device or tubal ligation) for 1 month.
For postmenopausal women: confirmatory diagnosis (non-medically induced amenorrhea for at least 12 months prior to the inclusion visit)
Patient who has read and understood the information letter and signed the consent form

Exclusion criteria

BMI≥ 30 kg/m2
Previously documented OSA (AHI > 10/h)
Patient with a CPAP or NIV
Patient on systemic corticosteroid therapy
Patient on centrally acting therapy (benzodiazepine or opiate)
Patient with an occurrence of severe COPD exacerbation
Patient with other associated chronic respiratory insufficiency
Patient with active cancer
Patient with neuromuscular disease
Patient with an osteoarticular disability or traumatic or neurological sequelae preventing participation in the respiratory rehabilitation program
Psychiatric, cognitive or linguistic disorders with inability to understand to follow the protocol
Patient with a contraindication to respiratory rehabilitation or any pathology preventing physical rehabilitation
Patient with a cardiovascular contraindication to respiratory rehabilitation
Person deprived of liberty by an administrative or judicial decision or person placed under judicial safeguard, guardianship or curatorship
Person subject to a legal protection measure
Pregnant or parturient or breastfeeding woman