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Respiratory Variability in Aortic Blood Velocity Measured by Suprasternal View as an Indicator of Fluid Responsiveness (SUPRA-PAM)

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Civil Hospices of Lyon

Status

Completed

Conditions

Cardiovascular System

Treatments

Device: Fluid challenge with 250 ml of Ringer Lactate

Study type

Interventional

Funder types

Other

Identifiers

NCT02791984
69HCL14-0408

Details and patient eligibility

About

Respiratory changes in aortic blood velocity have been described as an indicator of fluid responsiveness when measured in the left ventricular outflow tract by trans esophageal echography. A threshold value of 12% allowed discrimination between responders and nonresponders with a sensitivity of 100% and a specificity of 89%. The suprasternal window is already used to measure cardiac output. The primary endpoint of this study is to determine the predictive value of the respiratory variability in aortic blood velocity measured by suprasternal view (∆VpicSS) as an indicator of fluid responsiveness. The secondary endpoint is to compare maximum velocity and velocity time integral measured by suprasternal and transthoracic view.

Enrollment

62 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age more than 18 years
  • American Society of Anesthesiologists (ASA) score 1 or 2
  • General Anesthesia with mechanical ventilation
  • General Surgery

Exclusion criteria

  • Arrhythmia
  • Spontaneous breathing activity
  • Significant valvular disease

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

62 participants in 1 patient group

Fluid challenge with 250 ml of Ringer Lactate
Experimental group
Treatment:
Device: Fluid challenge with 250 ml of Ringer Lactate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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