Respiratory Variations For Assessing Blood Withdrawal (ReVAs)

University Hospital, Lille

Status: Completed

Conditions: Genetic Hemochromatosis

Treatments: Procedure: echography

Study type: Observational

Funder types: Other

Identifiers

NCT03066414

2013-A01689-36 (Other Identifier)

2013_38

Details and patient eligibility

About

OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in spontaneously breathing and non-obese patients with genetic hemochromatosis.

DESIGN: Prospective, monocentric study in the EFS Nord-de-France blood center.

PATIENTS: Non-obese patients with genetic hemochromatosis undergoing a therapeutic bleeding.

INTERVENTIONS: Ultrasound measures and collected clinical parameters before and after a therapeutic bleeding, during a standardized respiratory maneuver.

MAIN OUTCOME AND MEASURES: The primary endpoint was the ΔIVCST change induced by a 300 to 500ml therapeutic bleeding. It measured the minimal and maximal IVC and IJV diameters during a standardized respiratory maneuver. ΔIVCST and ΔIJVST were calculated as follows: [(maximal diameter - minimal diameter)/maximal diameter].100.

Enrollment: 27 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients of > or equal 18 years
• genetic hemochromatosis
• undergoing a therapeutic blood withdrawal
• health insured
• non-obese (body mass index <30Kg/m²)

Exclusion criteria

• pregnancy
• transthoracic echogenicity unsuitable for measuring the inferior vena cava diameters
• clinical signs of active exhalation

Trial design

27 participants in 1 patient group

non-obese patients with genetic hemochromatosis

Description:

PATIENTS: Non-obese patients with genetic hemochromatosis undergoing a therapeutic bleeding. INTERVENTIONS: The investigators performed ultrasound measurements (echography) and collected clinical parameters before and after a 300 to 500ml therapeutic bleeding, during a standardized respiratory maneuver.

Treatment:

Procedure: echography