Respiratory Variations for Assessing Blood Withdrawal 2 (ReVAs2)

University Hospital, Lille

Status: Terminated

Conditions: Obese; Dysmetabolic Syndrome; Hyperferritinemia

Treatments: Procedure: echography

Study type: Observational

Funder types: Other

Identifiers

NCT03066401

2013_37

2013-A01684-41 (Other Identifier)

Details and patient eligibility

About

OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in spontaneously breathing and obese patients with dysmetabolic hyperferricemia.

DESIGN: Prospective, monocentric study in the EFS Nord-de-France blood center.

PATIENTS: Obese patients with dysmetabolic hyperferricemia undergoing a therapeutic bleeding.

INTERVENTIONS: The investigators performed ultrasound measures and collected clinical parameters before and after a therapeutic bleeding, during a standardized respiratory maneuver.

MAIN OUTCOME AND MEASURES: The primary endpoint was the ΔIVCST change induced by a 300 to 500ml therapeutic bleeding. The investigators measured the minimal and maximal IVC and IJV diameters during a standardized respiratory maneuver. ΔIVCST and ΔIJVST were calculated as follows: [(maximal diameter - minimal diameter)/maximal diameter].100.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients of > or equal 18 years
• dysmetabolic hyperferritinemia
• undergoing a therapeutic blood withdrawal
• health insured
• obese (body mass index > or equal 30Kg/m²)

Exclusion criteria

• pregnancy
• transthoracic echogenicity unsuitable for measuring the inferior vena cava diameters
• clinical signs of active exhalation

Trial design

5 participants in 1 patient group

obese patients with dysmetabolic hyperferritinemia

Description:

PATIENTS: obese patients with dysmetabolic hyperferritinemia undergoing a therapeutic bleeding. INTERVENTIONS: The investigators performed ultrasound measurements (echography) and collected clinical parameters before and after a 300 to 500ml therapeutic bleeding, during a standardized respiratory maneuver.

Treatment:

Procedure: echography