Respiratory Virus Infections in Acute Heart Failure

Minjae Yoon

Status: Enrolling

Conditions: Acute Heart Failure Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT06967441

SNUBH IRB NO: B-2412-941-302

Details and patient eligibility

About

Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.

The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Enrollment: 360 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult aged 19 years or older admitted to the cardiology department with acute heart failure
• NT-proBNP >300 pg/mL
• Clinician judgement of possible respiratory viral infection (fever >38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5 mg/dL)
• Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons

Exclusion criteria

• Patients with a clear other cause of acute heart failure (ex. STEMI, bradycardia requiring a pacemaker, SBP >200mmHg or DBP >110mmHg, haemoglobin <7g/dL)
• If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
• If there is a clear other source of infection that can explain the fever