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Response of Alkylresorcinols to Different Cereals

N

Nestlé

Status

Completed

Conditions

Healthy

Treatments

Other: Refined wheat flour
Other: Liquid wholegrain barley flour
Other: Esterase wholegrain wheat flour
Other: Wholegrain wheat flour
Other: Wholegrain barley flour
Other: Liquid whole grain wheat flour

Study type

Interventional

Funder types

Industry

Identifiers

NCT01287403
10.14 MET

Details and patient eligibility

About

Cereal grains contain a wide variety of different phytochemicals which may play different roles in physiology. Their response in plasma and urine after a meal is poorly defined for most cereals. This study will investigate the plasma response and urinary excretion of cereal compounds after eating 6 different types of cereal preparation, with a focus on alkylresorcinols.

Full description

This was a cross-over, randomized, double blind study with 6 arms (flours of different composition). Thirteen subjects completed the trial, where 100 g of each flour, mixed with 300 mL milk, was fed to all subjects.

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Enrollment

14 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • Normal-overweight (BMI 19-28 kg/m2)
  • Non-smokers

Exclusion criteria

  • Regular consumers of wholegrain cereals
  • Allergy to cereal or milk products

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Quadruple Blind

14 participants in 6 patient groups, including a placebo group

Refined wheat flour
Placebo Comparator group
Description:
A negative control flour to serve as a reference.
Treatment:
Other: Esterase wholegrain wheat flour
Other: Wholegrain barley flour
Other: Liquid whole grain wheat flour
Other: Wholegrain wheat flour
Other: Liquid wholegrain barley flour
Esterase wholegrain wheat flour
Active Comparator group
Description:
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
Treatment:
Other: Wholegrain barley flour
Other: Liquid whole grain wheat flour
Other: Wholegrain wheat flour
Other: Liquid wholegrain barley flour
Other: Refined wheat flour
Wholegrain wheat flour
Experimental group
Description:
Flour with unknown response
Treatment:
Other: Esterase wholegrain wheat flour
Other: Wholegrain barley flour
Other: Liquid whole grain wheat flour
Other: Liquid wholegrain barley flour
Other: Refined wheat flour
Liquid whole grain wheat flour
Experimental group
Description:
Test flour with unknown response.
Treatment:
Other: Esterase wholegrain wheat flour
Other: Wholegrain barley flour
Other: Wholegrain wheat flour
Other: Liquid wholegrain barley flour
Other: Refined wheat flour
Wholegrain barley flour
Experimental group
Description:
Test flour with unknown response.
Treatment:
Other: Esterase wholegrain wheat flour
Other: Liquid whole grain wheat flour
Other: Wholegrain wheat flour
Other: Liquid wholegrain barley flour
Other: Refined wheat flour
Liquid wholegrain barley flour
Experimental group
Description:
Test flour with unknown response.
Treatment:
Other: Esterase wholegrain wheat flour
Other: Wholegrain barley flour
Other: Liquid whole grain wheat flour
Other: Wholegrain wheat flour
Other: Refined wheat flour

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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