Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction

Chien-Chung,Huang

Status: Completed

Conditions: Intubation, Intratracheal

Treatments: Other: Different given time

Study type: Interventional

Funder types: Other

Identifiers

NCT03728686

16MMHIS097e

Details and patient eligibility

About

Opioids have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine. Patients'details will be recorded too.

Full description

Laryngoscopy and intubation often provoke hypertension and tachycardia due to the stimulation both sympathetic and sympathoadrenal activities. While the adverse hemodynamic effects of laryngoscopy and endotracheal intubation can precipitate myocardial ischemia, even in patients without hypertension, the responses are exaggerated in patients with hypertension . In the previous studies , many drugs, including opioids and beta-blockers, have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine.

All patients were premedicated with Midazolam 0.1mg/kg , Lidocaine 0.5mg/kg (L), Propofol 2mg/kg (P), Rocuronium 1mg/kg (R) before induction of general anesthesia. Laryngoscopy lasting a maximum of 30 s was attempted 3 min after administration of the induction agents. Fentanyl 2mcg/kg was given at different time before intubation.

Enrollment: 101 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• with American Society of Anesthesiologists (ASA) physical status classification 1&2
• undergo elective surgery
• intubation

Exclusion criteria

• Opioids allergy history

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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101 participants in 3 patient groups

3mins

Experimental group

Description:

Different given time: Fentanyl 2mcg/kg was given at either time 3 minutes before intubation

Treatment:

Other: Different given time

2mins

Active Comparator group

Description:

Different given time: Fentanyl 2mcg/kg was given at either time 2 minutes before intubation

Treatment:

Other: Different given time

control

No Intervention group

Description:

Different given time: Fentanyl 2mcg/kg was given at either time 1 minute before intubation