Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Withdrawn

Conditions: Chest Wall Disorders; Neuromuscular Disorders; Obesity Hypoventilation Syndrome (OHS)

Treatments: Device: Controlled Ventilation Mode; Device: Simulator Ventilation Mode; Device: Spontaneous Ventilation Mode

Study type: Interventional

Funder types: Other

Identifiers

NCT01991535

IIBSP-VEN-2013-23

Details and patient eligibility

About

The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.

Full description

Breathing pattern will be analyzed along the adaptation to 3 different NonInvasive-Mechanical-Ventilation modes (controlled mode, spontaneous mode and placebo mode or simulator).

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hypercapnic chronic respiratory failure due to restrictive pulmonary disease (with usual criteria for home NonInvasive Mechanical Ventilation).
• Transcutaneous carbon dioxide (CO2) basal pressure ≥ 50 mmHg when conscious.
• Clinically stable (within the previous month).
• Patients without previous NonInvasive Mechanical Ventilation treatment.

Exclusion criteria

• Clinical exacerbation.
• Chronic airflow limitation Forced expiratory volume in 1 second/Forced vital capacity (FEV1/FVC) ratio < 70% or Sleep Apnea-Hypopnea Syndrome