Rest Ventilatory Parameters Predict Morbidity and Mortality in Thoracic Surgery

St. Anne's University Hospital Brno, Czech Republic

Status: Completed

Conditions: Cardiovascular Complication; Pulmonary Complication

Treatments: Procedure: Thoracic surgery

Study type: Observational

Funder types: Other

Identifiers

NCT03498352

IIT/2017/12 and 2018/08

Details and patient eligibility

About

Cardiopulmonary exercise testing is recommended for preoperative evaluation and risk stratification of lung resection candidates. Ventilatory efficiency (VE/VCO2 slope) has been shown to predict morbidity and mortality in lung resection candidates and has been shown superior to peak oxygen consumption (VO2). Patients with increased VE/VCO2 during exercise also exhibit increased VE/VCO2 ratio and decreased end-tidal CO2 at rest. Our first hypothesis is that rest ventilatory parameters predict morbidity and mortality in patients undergoing thoracic surgery. VE/VCO2 is well correlated with ventilation-perfusion mismatch, therefore it may be useful in hypoxemia prediction during one-lung ventilation during thoracic surgery. Our second hypothesis is that patients with high VE/VCO2 will be prone to hypoxemia development during one-lung ventilation.

Enrollment: 366 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thoracotomy because of lung infiltration (confirmed or highly suspicious lung tumor)

Exclusion criteria

• none