Resting Energy Expenditure and Substrate Consumption in Cardiac Arrest Patients Under Target Temperature Management

Tang Ziren

Status

Enrolling

Conditions

Resting Energy Expenditure

Nutrition

Cardiac Arrest

Targeted Temperature Management

Treatments

Procedure: Target Temperature Management Treatment

Study type

Observational

Funder types

Other

Identifiers

NCT06575101

2024-4-15-1

Details and patient eligibility

About

This study is a single-center, prospective, observational study. According to the sample size formula, an estimated 40 cases should be collected, all of whom are from the emergency intensive care unit. After successful cardiopulmonary resuscitation, the enrolled patients will be transferred to the emergency intensive care unit for further standardized target temperature management (TTM). They will be divided into 33 ° C hypothermia group and 36 ° C hypothermia group according to the patient's core body temperature. The baseline data of the patients will be collected at the beginning. After admission to the hospital, they were fasted within 24 hours to reach the target temperature, and then 20kcal/kg/d parenteral nutrition will be given. At selected time points (T0: the initial time point before TTM; T1: the core temperature was reduced to 33 ° C or 36 ° C; T2-T4: 33 ° C or 36 ° C was maintained for 24h, 48h, 72h; T5: the end of rewarming; Tend: the last REE measurement before discharge or death) , various observation indicators will be collected, including resting energy expenditure (REE), glucose oxidation rate, fat oxidation rate, protein oxidation rate, and metabolism of three major nutrients Proportion. Neurological outcomes were followed up 28 days after onset according to the Cerebral Performance Categories (CPC) score.

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University;
Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC);
Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC);
Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC);

Exclusion criteria

Age > 18 years old；
Incomplete clinical data and loss of follow-up;
Traumatic brain injury or cerebrovascular accident revealed by computed tomography (CT)；
Severe metabolic abnormalities are known: cachexia, thyroid dysfunction, and cancer；
Indirect calorimetry measurement is not possible such as sustained oxygen concentration > 70%；
There were no signs of resuscitation at the time of admission；