Resting Postural Tremor in Multiple Sclerosis

Charles University, Czech Republic

Status

Enrolling

Conditions

Multiple Sclerosis

Treatments

Behavioral: Examination of tremor and upper hand functions

Study type

Observational

Funder types

Other

Identifiers

NCT04405479

EK-VP/23/0/2014

Details and patient eligibility

About

Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.

Full description

The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis.

Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.

Enrollment

30 estimated patients

Sex

All

Ages

20 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Group 1:

Definite diagnosis of MS
prevailed motor deficit of upper extremities, but without visible tremor
stable clinical status in the preceding 3 months
Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and
no corticosteroid therapy in the preceding month

Group 2:

Healthy volunteers in the age of 20-70 years will be employed
There will be defined as persons without any neurological disease diagnose at the time of the measurement.

Exclusion Criteria (both groups):

Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.