Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

Hangzhou Normal University

Status: Unknown

Conditions: Jaundice

Treatments: Device: light treatment

Study type: Observational

Funder types: Other

Identifiers

NCT02224586

HNU_AH_jaundice fMRI

Details and patient eligibility

About

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Full description

resting state fMRI scan light therapy the second time resting state fMRI scan

Enrollment: 20 estimated patients

Sex: All

Ages: 1 to 28 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hyperbilirubinemia

Exclusion criteria

• asphyxia
• cerebral dysgenesis

Trial design

20 participants in 1 patient group

light treatment

Description:

clinical routine treatment according to the doctor's advice

Treatment:

Device: light treatment