RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy (RESPIRE)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Enrolling

Conditions: Epilepsy

Study type: Observational

Funder types: NETWORK

Identifiers

NCT04451278

2020-A01561-38

Details and patient eligibility

About

Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the calculation of quantifiable parameters applied to the functional network studied, making it possible to assess its effectiveness.

To the knowledge of the investigators, no study has used graph theory applied to r-fMRI data in order to obtain parameters useful for the useful parameters for the individual prognosis of children who have to be operation for drug-resistant lesional epilepsy.

Enrollment: 200 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient aged between 6 and 18 years
• Receiving an MRI for lesional drug-resistant epilepsy
• Affiliated or beneficiary of a social security plan
• Whose parents or guardians have received information about the study and have given their express consent to participate in the study

Exclusion criteria

• Contraindication to absolute or relative MRI (in particular, pregnant or breastfeeding women)
• History of intracranial surgery
• MRI performed under general anesthesia

Trial design

200 participants in 1 patient group

Resting-state functional MRI (r-fMRI)

Description:

The MRI examination will be performed on a 3T multi-parametric MRI. Compared to the standard protocol, patients will benefit from an additional fMRI-r sequence, called resting state, and performed before injection of gadoline contrast. A neuropsychological evaluation is performed as part of the 6 months prior to the procedure. These data will be used as a basis for the evaluation of language visual and language recovery.