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The objective of this study is to determine the efficacy and safety of Restylane® Silk microinjections when used in a grid-like injection pattern for the correction of fine lines to the cheeks.
Full description
Silk for correction of mid to low cheek fine lines and wrinkles. Twenty (20) subjects will be enrolled. Each subject will receive Restylane® Silk to the entire cheeks. The defined area will be defined as the following: line extending from the upper margin of the nasal ala to the upper margin of the tragus, from the tragus to 1 cm above the mandibular angle, from 1 cm above the mandibular angle to 1 cm above the pre-jowl sulcus, and from 1 cm above the pre-jowl sulcus to the upper margin of the nasal ala. The injections will be delivered intradermally via multiple 0.02 cc microinjections distributed in a grid array pattern with 1-2 cm between each injection point (see figure 1; injections will extend 1 cm above the illustration). Following completion of injection treatment, manual massage will be applied to the full area to promote even distribution of the product. Each subject will undergo a total of three treatment sessions, one month apart, day 1, week 4, and week 8. The maximum amount of Restylane to be used per treatments session/per cheek is 1.5cc (not to exceed a total of 9 cc) per treated patient. Three-dimensional digital photography utilizing the Vectra 3D System (Canfield) will be utilized to document pre-treatment status, sites of injection, and post-treatment effect. Subjects will be followed up at 4 weeks, 8 weeks, post-treatment day 90, and day 180. Objective measures of efficacy will be me performed pre-treatment, at day 90 and 180.
Enrollment
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Inclusion and exclusion criteria
Inclusion Criteria:
b. Symmetrical visible sign of aging involving at least a 9 cm2 area of the mid to low cheeks.
c. Must be willing to give and sign a HIPPA form, photo consent and informed consent form.
d. Must be willing to comply with study dosing and complete the entire course of the study.
e. Female patients will be either of non-childbearing potential defined as:
Having no uterus 2. No menses for at least 12 months. Or; (WOCBP) women of childbearing potential must agree to use an effective method of birth control during the course of the study, such as:
Oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine device
Intrauterine coil
Bilateral tubal ligation
Barrier method used with an additional form of contraception (e.g., sponge, spermicide or condom)
Abstinence (If practicing abstinence must agree to use barrier method described above (4) if becomes sexually active).
Vasectomized partner (must agree to use barrier method described above (4) if becomes sexually active with un-vasectomized).
f. Negative urine pregnancy test results Baseline prior to study entry (if applicable)
Exclusion Criteria:
Primary purpose
Allocation
Interventional model
Masking
20 participants in 1 patient group
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Central trial contact
Shannon Quigley
Data sourced from clinicaltrials.gov
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