Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient

Universitas Sriwijaya

Status: Completed

Conditions: Sepsis

Treatments: Diagnostic Test: Blood Collection

Study type: Observational

Funder types: Other

Identifiers

NCT04169412

047/kepkrsmhfkunsri/2019

Details and patient eligibility

About

Resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient

Full description

This prospective cohort study was conducted at resuscitation room and ICU of Mohammad Hoesin hospital, a single tertiary teaching hospital in Palembang, South Sumatera. This study was started after ethical and location authorization were unleashed in February to August 2019. Inclusion criteria were patients aged 18 years old or above who met Sepsis-3 definition and diagnosed with sepsis. Exclusion criteria were patients whose family did not give any consent to participate, not treated at the ICU, had a late diagnosis (>24 h), pregnant, and diagnosed with brain dead. Drop out criteria including patients who died <4 h after diagnosed and could not be followed in 28 days. Investigators were trained to identified all eligible subjects. All the subjects had a standard resuscitation and their blood was taken to be examined at the laboratory. Subjects were observed in 28 days whether there were any mortality or not. Failed resuscitation defined by examined lactate level ≥ 2 mmol/L or lactate reduction <20%. Data was statistically analyzed with STATA™

Enrollment: 72 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants aged 18 years old or above
• Diagnosed sepsis using Sepsis-3 definition

Exclusion criteria

• Participants whose family did not give any consent to participate
• Not treated at the ICU
• Had a late diagnosis (>24 h)
• Pregnant
• Brain dead

Trial design

72 participants in 2 patient groups

Resuscitation Failure, High PCO Level, High RIPK3 Level

Description:

1. Resuscitation failure was defined as lactate level ≥2 mmol/L or lactate reduction \<20% hour-4 after initial sepsis recognition. 2. High PCO level was defined as PCO level ≥ cut off point. 3. High RIPK3 level was defined as PCO level ≥ cut off point.

Treatment:

Diagnostic Test: Blood Collection

Resuscitation Success, Low PCO Level, Low RIPK3 Level

Description:

1. Resuscitation success was defined as lactate level \<2 mmol/L or lactate reduction ≥20% hour-4 after initial sepsis recognition. 2. Low PCO level was defined as PCO level \< cut off point. 3. Low RIPK3 level was defined as PCO level \< cut off point.

Treatment:

Diagnostic Test: Blood Collection