Resveratrol In Chronic Obstructive Pulmonary Disease (COPD) Patients (CARMENS-trial)

Maastricht University Medical Centre (MUMC)

Status

Completed

Conditions

Pulmonary Disease, Chronic Obstructive

Treatments

Dietary Supplement: Resveratrol

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02245932

143031

3.4.12.023 (Other Grant/Funding Number)

Details and patient eligibility

About

The primary objective is to investigate the efficacy of resveratrol on mitochondrial function in patients with COPD. The secondary objective is to investigate the effect of resveratrol on body composition, inflammatory status and mechanistic markers in blood, adipose and muscle tissue as well as a comprehensive assessment of metabolicand physical performance profile known to be affected by resveratrol.

Full description

Rationale: Patients with COPD are often chaacterized by disturbed metabolic health affecting physical and cognitive function, which is reflected in altered body composition. current studies in healthy subjects suggest that resveratrol improves metabolic health by enhancing muscle mitochondrial function and adipose tissue morphology.

Study design: Proof-of-concept randomized placebo-controlled double blinded clinical trial of 4 weeks.

Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Subjects may be confronted with certain inconveniences and risks. Subjects will be asked to wear an accelerometer two times for one week. During the entire study period subjects will visit the MUMC+ 2 times for various non-invasive measurements (questionnaires, anthropometry, and physical function test) as well as some minor invasive procedures (venous blood sampling and muscle and fat biopsies) which can cause a local haematoma afterwards. However, the patients will be informed about their metabolic and cardiovascular health, which we expect to be positively affected by the intervention. In addition, all patients will receive a lifestyle advice tailored to their health status.

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

COPD patients
Current or ex-smoker
Age >18 years

Exclusion criteria

COPD patients planned for pulmonary rehabilitation or who recently participated in a rehabilitation program in the previous 6 months
Investigator's uncertainty about willingness or ability of the patient to comply with the protocol requirements
Participation in any other study involving investigational exercise training, nutritional or pharmacological intervention
Oral glucocorticoid use
Recent exacerbation (<4 weeks) that required oral steroids and/or hospital admission
Subject is pregnant, planning to be pregnant during the study period, lactating, or women who consider themselves to be of childbearing potential and who are engaged in an active sex life and are unwilling to commit to the use of an approved form of contraception throughout the study period. The method of contraception must be recorded in the source documentation;
Diabetes mellitus (all types), active cardiovascular disease or a cardiovascular event (such as myocardial infarction, cerebrovascular haemorrhage/infarction) in the previous 6 months, recent major surgery, thyroid dysfunction, hepatic or renal disorders, current malignancy (except for dermal malignancies) or central or obstructive sleep apnea;
Current alcohol consumption > 20 grams alcohol/day;
Intake of resveratrol containing dietary supplements.