Retention Rates of Adalimumab, Etanercept and Infliximab as First and Second-Line Biotherapy in Patients With Rheumatoid Arthritis in Daily Practice (MAINTAIN)
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To compare retention rates of adalimumab, etanercept and infliximab as first-line biotherapy in rheumatoid arthritis (RA), to determine causes of discontinuation, retention-associated factors, and retention rates of possible second-line tumor necrosis factor α inhibitors (TNFi).
Full description
In this retrolective, multicentric study, medical charts of RA patients starting TNFi between March 2005 and April 2009 were reviewed, with follow-up between 2 and 6 years. The retention rate was estimated using the Kaplan-Meier method. Comparison between TNFi was done after adjustment using a Cox model. Factors associated with better retention were identified by multivariate analysis. Medical charts of all patients with RA starting a first TNFα inhibitor therapy between March 1, 2005 (start of commercialization of adalimumab in France) and April 30, 2009 (allowing at least 2 years of follow-up) were systematically reviewed in detail by 2 rheumatologist investigators
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Inclusion criteria
- RA defined by the 1987 ACR criteria [18]
- first TNFα inhibitor prescribed in the previously mentioned period
- TNFα inhibitor prescribed as first-line biotherapy
- undergone at least one evaluation in the center after treatment initiation
Exclusion criteria
- previously received another biotherapy
- TNFα inhibitor was prescribed in an RCT
- refused to participate
Trial design
780 participants in 3 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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