Retina BioBank: Retina Biomarkers for a Deeper Understanding of Vitreoretinal and Systemic Diseases (RBBK)

Greater Houston Retina Research

Status: Invitation-only

Conditions: Retinal Vascular Disorder; Other Retinal Disorders; Retinal Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06796673

RBBK

Details and patient eligibility

About

The RBBK study is a non-interventional, prospective study that will characterize disease state biomarker levels from aqueous humor, vitreous humor, intraoperative tissue and saliva of subjects with various retinal and systemic pathologies.

Full description

The RBBK study is a non-interventional, prospective study that will characterize disease state biomarker levels from aqueous humor, vitreous humor, intraoperative tissue and saliva of subjects with various retinal and systemic pathologies.

Participants are eligible to be included in the study only if all of the following criteria apply:

1. Men or women > 18 years of age
2. Subjects with vitreoretinal disease in at least one eye receiving a retinal treatment intervention
3. Able and willing to provide signed informed consent

The study will consist of a single visit and a retrospective chart review. The study visit will consist of:

1. Screening for eligibility;
2. Aqueous humor collection (if applicable);
3. Vitreous humor collection (if applicable);
4. Intraoperative tissue (if applicable); and
5. Saliva collection

If applicable, approximately 50 microliters (or more, up to 1000 microliters) of aqueous fluid will be collected by anterior chamber paracentesis according to standard clinical procedures. If applicable, up to 2 milliliters of vitreous fluid will be collected according to standard clinical procedures. Specific tissue, such as scar tissue, are routinely removed from the eye during vitreoretinal procedures. When being removed during a standard of care surgical procedure, these tissues may be collected. Saliva will also be collected according to instructions found in the Saliva Oragene Dx Collection Kit.

Enrollment: 10,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Subjects with vitreoretinal disease in at least one eye receiving a retinal treatment intervention

Exclusion criteria

1. Prior intraocular or subtenon steroid injection in the study eye within the prior 1 month of signing informed consent
2. Intraocular or refractive surgery in the study eye within 30 days of signing informed consent
3. Systemic anti-VEGF treatment within 90 days of signing informed consent