Retina Microvascularisation and Cardiovascular Heart Disease Prediction

U

University of Montreal

Status

Completed

Conditions

Cardiovascular Disease

Study type

Observational

Funder types

Other

Identifiers

NCT01027988
ICM 08-1050

Details and patient eligibility

About

Earlier studies have found that retinal photography could be very useful for evaluating the condition of microcirculation and the risk of cardiovascular diseases in patients. The architectural changes in retinal vascularisation strongly correlates with macrovascular remodeling. Also, recent founding suggests a possible close anatomical parallel between both the macrovascular and the microvascular blood. Our objectives are to assess (1) in which age and sex subgroups, if any, retinal vascular alteration in arterioles and venules can be predictive for cardiovascular morbidity and mortality; and (2) whether variations in arteriolar or venular caliber will predict better cardiovascular pathogenesis in normal and patient population. If the association between the diameter of the retinal vessels and the risks of cardiovascular disease is verified during this study, the impact on prevention would be enormous. The retinal microvascular change could become a powerful biomarker in the early detection of the cardiovascular pathogenesis and death risk

Enrollment

40 patients

Sex

All

Ages

50 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age between 50 to 70 years old (male/female) indication of coronarography within the last 3 month preceding the enrollment Patients with history of stroke, heart failure or arteriosclerosis. At least one of the following risk factors for cardiovascular complication: Hypertension Coronary heart disease (CHD) Diabetes Structural heart disease Dyslipidemia Obesity

Exclusion criteria

Patients with a permanent pacemaker or ICD Nephrosis or chronic renal failure The study interferes with therapeutic or diagnostic procedures Patients with inability to consent or comply with follow up requirements Patients with glaucoma Patients with any retina degeneration disease vascular age-related macular degeneration or any -retina degeneration disease Patients who are pregnant

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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