Retinal and Choroidal Microvascular Changes During Pregnancy Period Detected With Optical Coherence Tomography Angiography

Akdeniz University

Status: Terminated

Conditions: Pregnancy Related

Treatments: Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)

Study type: Observational

Funder types: Other

Identifiers

NCT04950855

Study1

Details and patient eligibility

About

During pregnancy many physiological changes and adaptations occur.Hormonal, hematological and hemodynamic changes are responsible for most of the ocular adaptations.We are planning to compare the choroid and retinal blood flow values and choroidal thickness of pregnant women and healthy non pregnant women with optical coherence tomography and optic coherence tomography angiography

Full description

During pregnancy many physiological changes and adaptations occur such as pulmonary, renal, endocrinological, haematological and visual system changes are happening. In previous studies, retinal and choroidal pregnancy-related changes in blood flow and choroidal thickness have been demonstrated. Optical coherence tomography angiography (OCTA) detects the contrast of motion in the blood flow, detecting the capillary of the retina and choroid.

It is a new functional method that visualizes the retinal networks and outer retina without using dyes.It is a non-invasive method that provides volumetric angiography information. In this study evaluation of the variability of choroidal and retinal blood flow changes and choroidal thickness, between trimesters of pregnancy and the non-pregnant control group is planned. Choroid and Retinal Blood Flow Values and Choroidal thickness in 41 pregnant women in the first trimester and it would be repeated at second and third trimesters. We compare measured values between trimesters and 45 healthy non-pregnant women.

Enrollment: 86 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy pregnant women Age > 18 years

Exclusion criteria

• Systemical disease such as diabetes mellitus or hypertension
• Refractive error; spherical equivalence > 4 diopters
• Ocular disease or surgery history

Trial design

86 participants in 2 patient groups

Pregnant Women

Description:

Healty pregnant women between 18-45 years,with no history of eye surgery and systemical disease.In 1st , 2nd and 3rd trimesters the measurements will be repeated

Treatment:

Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)

Control Group

Description:

Healty non-pregnant women between 18-45 years with no history of eye surgery and systemical disease.

Treatment:

Diagnostic Test: Optical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)