Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism

Glostrup University Hospital, Copenhagen

Status: Unknown

Conditions: Patients With Diabetes.; Healthy Individuals

Treatments: Other: Hyperoxia; Other: Glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT01721811

Klefter2

Details and patient eligibility

About

The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Healthy individuals

Inclusion Criteria:

• Healthy volunteers.
• No known systemic or ocular disease.

Exclusion Criteria:

• Any systemic or ocular disease.

Patients with diabetes

Inclusion criteria:

• Diabetes mellitus
• No intraocular disease other than conditions attributable to diabetes.

Exclusion criteria:

• Intraocular disease other than conditions attributable to diabetes.
• Systemic conditions which might contraindicate hyperoxic stimulation.

Trial design

120 participants in 2 patient groups

Healthy

Experimental group

Description:

Healthy study participanats

Treatment:

Other: Glucose

Other: Hyperoxia

Diabetes

Experimental group

Description:

Patients with diabetes

Treatment:

Other: Glucose

Other: Hyperoxia