Retinal Microvascularization in OCT-angiography and Systemic Diseases (OCTAVA)

University Hospital Center (CHU) Dijon Bourgogne

Status

Enrolling

Conditions

Systemic Vascular Damage

Treatments

Biological: Biological check-up

Other: Retinal imaging

Study type

Observational

Funder types

Other

Identifiers

NCT06613555

ARNOULD 2022

Details and patient eligibility

About

Systemic diseases are inflammatory, chronic illnesses affecting different organs and altering their function. At present, there are few non-invasive methods for predicting their onset and progression.

Some chronic diseases can be anticipated earlier thanks to predictive indicators. These indicators could help doctors decide which treatment is best suited to each patient. In particular, the state of microcirculation in the eyes, specifically in the retina, is linked to the progression of certain diseases in the body. Unfortunately, assessing the health of the small blood vessels in the retina is complicated. Most current methods are imprecise, difficult to reproduce and require qualified specialists. However, the use of retinal microcirculation appears to be a promising approach to solving these problems.

In fact, the structure of retinal blood vessels can be observed easily, painlessly and without invasive procedures, thanks to fundus photographs or scans providing imaging slices known as optical coherence tomography-angiography (OCT-A).

The vascularization of the retina is very often presented as a window giving access to the peripheral vascularization (the vascularization of other organs distant from the eyes).

For example, we recently demonstrated a link between retinal vascularization and the risk of heart problems in patients with coronary artery disease.

The aim of this study is to gather original information on the evolution of retinal vascularization, using specific markers that may be associated with damage to distant organs.

By regularly monitoring these changes over time, the researchers hope to identify early changes that could indicate the development or evolution of these diseases.

The main aim of this study is to create a database of images obtained by OCT-Angiography in patients with systemic diseases and in healthy individuals. This will enable us to identify early changes in retinal vascularization that may be associated with these systemic pathologies.

With this information, we hope to improve early diagnosis and monitoring of diseases, which could have a positive impact on patients' health.

Enrollment

5,000 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

For the "patients with systemic vascular disease" group

Patients who have given oral, free and informed consent
Patients with either :
- systemic vascular pathology
- high cardiovascular risk
- inflammatory vascular pathology
- preeclampsia during pregnancy

The study will also be offered to patients who have already had an OCT-A examination as part of their routine care, in order to follow them over time.

For the "healthy control" group

Patients who have given free, oral and informed consent
Patients with no prior systemic or vascular inflammatory pathology, and no high cardiovascular risk
Non-diabetic patients
Pregnant patients with risk-free pregnancies recruited from the gynecology department of CHU Dijon Bourgogne OR
Adult patients without maculopathy recruited from the Ophthalmology Department of CHU Dijon Bourgogne

Exclusion criteria

For the "patients with systemic vascular disease" group
Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
Protected patient :
- Minor patient
- Patient under legal protection (guardianship, curatorship, court order)
- Patient unable to give consent Person not affiliated to a social security scheme
- Breast-feeding women
Person with a contraindication to Tropicamide
OCT-A signal strength < 7

For the "healthy control" group

Any pathology studied in the case group
Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
Type 1 or type 2 diabetes
Person with a contraindication to Tropicamide
Protected person :
- Minor
- Person under legal protection (guardianship, curatorship, court order)
- Person unable to give consent
- Person not affiliated to a social security scheme
- Breast-feeding women
OCT-A signal strength < 7