Retinal Microvasculature by Optical Coherence Tomography Angiography During Integrating Physical Activity in Diabetic Subjects. (OCTACTIPH)

Toulouse University Hospital

Status

Enrolling

Conditions

Diabetes Complications

Treatments

Diagnostic Test: Optical Coherence Tomography Angiography

Other: multidisciplinary care program

Study type

Interventional

Funder types

Other

Identifiers

NCT05645068

2022-A02003-40 (Other Identifier)

RC31/21/0612

Details and patient eligibility

About

Diabetic retinopathy is a common condition of diabetes and can lead to blindness, making it one of the most feared complications of diabetes.

Recently, it has been proven that the parameters measured by Optical Coherence Tomography (OCT) Angiography: the vascular density of the macular retinal capillary plexi and the foveolar avascular zone, can be modified after a high-intensity sports training program in healthy subjects.

the team wants to study the evolution of the macular, in type 2 diabetic subjects, before and after a stay in a care structure dedicated to the multidisciplinary and integrative management (nutrition, physical activity, therapeutic education) of a duration of 3 weeks.

Full description

The prevention of vascular and neurological complications in diabetic subjects represents a major public health issue. Diabetic retinopathy is a common condition of diabetes and can lead to blindness, making it one of the most feared complications of diabetes.

Diabetes management is global and aims at a stable glycemic balance putting the patient out of the micro and macrovascular complications linked to this pathology. It involves modifying the lifestyle of patients with the practice of appropriate physical activity, balancing daily food intake, not necessarily by taking insulin-sensitizing or hypoglycemic drug treatment, but also by management of other risk factors related to complications: dyslipidemia, weight, smoking, arterial blood pressure balance.

The use of Optical Coherence Tomography Angiography allow the evaluation of the microvasculature of the macula.

Diabetic macular edema is the leading cause of vision loss in type 2 diabetic subjects mainly due to dysfunction of the macular microvasculature.

Macular analysis via Optical Coherence Tomography Angiography can quickly and non-invasively predict the risk of occurrence of Diabetic macular edema and therefore that of a decrease in acuity and visual impairment.

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient for whom a 3-week multidisciplinary and integrative program was offered in a diabetology unit
Patient having given his consent
Patient affiliated to a social security scheme or equivalent
Patient with type 2 diabetes

Exclusion criteria

History of exudative or tractional retinal detachment
Intraocular foreign body
History of endophthalmitis
History of inflammatory disease of the retina
History of chorioretinitis
Patient with age-related macular degeneration
Patients with type 1 diabetes or secondary diabetes
Uncontrolled hypertension does not define Systolic arterial pressure (SAP) > 180 mmHg or Diastolic arterial pressure (DAP) > 110 mmHg
Patient who has already received intravitreal injections of anti-angiogenic molecules.
Pregnant or breastfeeding patient at the time of the study
Persons under a legal protection regime for adults (safeguard of justice, guardianship, curatorship, institutionalized, or under mandate for future protection)