Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor

H

Hospital Hietzing

Status

Completed

Conditions

Neovascular Age-related Macular Degeneration

Treatments

Device: OCT

Study type

Observational

Funder types

Other

Identifiers

NCT03679156
RPE characteristics

Details and patient eligibility

About

Purpose: To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis. Methods: 18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as-needed [pro re nata (PRN)]. Functional and morphological changes were assessed using spectral domain optical coherence tomography (SD-OCT).

Enrollment

18 patients

Sex

All

Ages

66 to 98 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Inclusion and exclusion criteria corresponded to the criteria of the MANTA study

Exclusion criteria

Inclusion and exclusion criteria corresponded to the criteria of the MANTA study

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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