Retinal Vascular Manifestations in Patients With Common Internal Diseases on OCTA Tomography Angiography

Capital Medical University

Status: Enrolling

Conditions: Hypertension; Dyslipidemias; Diabetes Mellitus

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05644548

YuHe2022

Details and patient eligibility

About

Hypertension, diabetes mellitus, and dyslipidemia are common internal diseases, and all diseases are atherosclerosis risk factors. Previous studies applied color fundus photography to analyze retinal vascular changes (including exudation, hemorrhage, neovascularization, etc.) in patients with hypertension or diabetes, but the examination results could not be quantified.

This study intends to apply optical coherence tomography angiography (OCTA) to examine retinal vessels. This method has the following advantages: 1) It can quantify vascular changes, and 2) It is noninvasive and reproducible for patients' follow-up.

This study was designed to investigate retinal vascular changes in patients with hypertension, diabetes, and dyslipidemia on OCTA. We will collect the patients' general information (gender, age), comorbidities, medications, blood lipids, blood glucose, carotid ultrasound, ankle-brachial index, ambulatory blood pressure monitoring, color fundus photography, and OCTA results. We will follow up with the patients for five years and conduct the mentioned examinations once a year. We will also investigate the correlation between systemic atherosclerosis (such as coronary artery stenosis, and carotid artery stenosis) and retinal vasculopathy in patients with these diseases.

Full description

Patients with hypertension, diabetes mellitus, or dyslipidemia, who go to the department of geriatric medicine, Beijing Tongren Hospital from March 2022 to December 2023 will be included. We will collect general information, comorbidities, medication, laboratory tests, and examination results. These patients will be followed up for 5 years with a yearly collection of comorbidities, medication, laboratory tests, and examination results.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with hypertension
• Or patients with diabetes
• Or patients with dyslipidemia
• Agree to participate in this study

Exclusion criteria

• Patients with malignant tumors
• Patients with autoimmune diseases
• Patients with immunodeficiency disease
• Disagree to participate in this study

Trial design

300 participants in 3 patient groups

Hypertension

Description:

No intervention

Treatment:

Other: No intervention

Diabetes mellitus

Description:

No intervention

Treatment:

Other: No intervention

Dyslipidemia

Description:

No intervention

Treatment:

Other: No intervention