Retinal Venous Pressure and ET-1 in Patients With Diabetes Mellitus

University Hospital Basel

Status: Completed

Conditions: Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT01771835

089-CYA-2012

Details and patient eligibility

About

Measurement of the circulation in patients with diabetes mellitus and establish a link between retinal venous pressure (RVP) and endothelin (ET-1)levels.

Full description

Diabetic retinopathy and maculopathy are the main causes of visual loss. Hyperglycemia as the main risk factor of diabetic retinopathy induced damage to retinal capillaries. These in turn lead to hypoxia in the tissue and promote the release of VEGF (vascular endothelial growth factor) , which in turn increases the vascular pathology. Simultaneously, there is an increased expression of endothelin (ET-1). Endothelin increases vascular tone and regulates the micro-and macro-vascular remodeling.

In ocular blood flow perfusion pressure plays an important role. While in healthy eyes a spontaneous retinal venous pulsation is frequently observed, this is significantly less frequent in diseased eyes. An increased venous pressure lowers the ocular perfusion pressure, and increases the transmural pressure. A measurement of the retinal venous pressure and the hormone ET-1 in the blood will give us a better knowledge of the circulatory changes and their relationship to diabetes.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetes mellitus type I or II
• no diabetic retinopathy

Exclusion criteria

• known diabetic retinopathy
• acute or chronic inflammation of the eyes
• narrow angle glaucoma
• minority

Trial design

20 participants in 1 patient group

Diabetes patients

Description:

Patients with diabetes mellitus type I + II, without diabetic retinopathy