Retinal Vessel Analysis (rGA) at the Patient Bed in the Context of Non-traumatic Subarachnoid Haemorrhage

RWTH Aachen University

Status

Unknown

Conditions

Non-traumatic Subarachnoid Haemorrhage

Treatments

Diagnostic Test: retinal vascular analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT04094155

14-061

Details and patient eligibility

About

A subarachnoid hemorrhage occurs in about 10 out of 100,000 people each year. This bleeding leads to irritation and constriction of blood vessels in the brain (vasospasm) in two out of three people affected within four to 21 days and thus to reduced blood flow. This can lead to a stroke and serious damage. In order to be able to diagnose and treat a constriction of the blood vessels at an early stage, there are various examination methods which, however, have various disadvantages such as radiation exposure of the patient, low sensitivity or high effort. Therefore, the prediction and timely therapy of vascular constrictions is currently only successful in a few cases before the reduced blood flow has already led to irreversible damage.

The aim of this study is to investigate whether the so-called retinal vascular analysis can be used in addition to previous standard examinations for the early detection of diseases of the cerebral blood circulation. This method has few side effects and has been successfully used for 50 years to examine the blood circulation in the eye.

Enrollment

150 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Female or male patient, age ≥ 18 years
Inpatient stay in the clinic
Written informed consent for participation in the study prior to beginning of treatment
Written consent for further evaluation of the images and for the scientific publication of the study results
Non-traumatic subarachnoid haemorrhage confirmed by computer tomography or magnetic resonance tomography or cerebrospinal fluid puncture (collection of nerve water from the lower part of the lumbar spine

Exclusion criteria

Female or male patient < 18 years
Pregnancy, Lactation
Lack of written consent to participate in the study and to further evaluate the image material collected
Known allergy to MS eye drops (active substance: phenylephrine/tropicamide
Narrow chamber angle, narrow angle glaucoma, Terson syndrome (if it makes retinal vascular imaging impossible
Persons in a dependency or employment relationship with the investigator
Persons who are accommodated in a facility by judicial or administrative order
Receipt and intake of a study drug within the last 30 days
Supine position in bed