Retinoic Acid Supplementation and Subjects With Hypercholesterolemia
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The aim of the study is to investigate the effects of retinoic acid on the HDL-PON1 activity and cholesterol efflux capacity in hypercholesterolemic subjects.
Full description
Paraoxonase 1 (PON1), an enzyme associated with high-density lipoprotein, is reported to have antioxidant and cardioprotective properties. And all-trans-retinoic acid revealed the ameliorating atherosclerosis effects in many reports.There maybe some correlations between retinoic acid and PON1 activity and the study aim to prove it.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- subject has a fasting total cholesterol concentration between 200 and 310mg/dl.
- subject is between 25 and 65 years of age, inclusive.
- subjects' BMI is between 18.5 kg/m2 and 35 kg/m2.
Exclusion criteria
- subject that is pregnant.
- subject that has coronafy artery desease, diabetes mellitus, thyroid disorders, mental disorder, cancer, cirrhosis, renal disease and hepatic desease.
- subject that has had operation less than six months prior to screening visit.
- subject that is smoking.
- subject uses any drugs that could influence the measurement of lipid paramerters or inflammatiory makers.
Trial design
Primary purpose
Allocation
Interventional model
Masking
130 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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