Retinol on Human Skin Aging in East Asian Descent

Stanford University

Status and phase

Completed

Phase 4

Conditions

Intrinsic Aging of Skin

Treatments

Drug: Placebo

Drug: Retinol

Study type

Interventional

Funder types

Other

Identifiers

NCT02906566

33762

Details and patient eligibility

About

There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.

Enrollment

110 patients

Sex

Female

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

able to provide written informed consent
older group: age between 50 and 75 years
young group: age 18 to 25 years
all four grandparents of Han Chinese, Japanese, Korean descent
body mass index within normal or overweight range
no history of weight loss of >20 lbs within past 5 years

Exclusion criteria

skin condition in the areas of skin biopsy that would obscure results of analysis
topical creams or treatment to arms 2 weeks prior to study baseline visit
individuals with known hypersensitivity to retinoid class of agents (older group only)
prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit
prior laser therapy or surgical procedure to arms
prior radiation or other trauma (extensive burns or abrasions) to arm skin
hormone-based therapy within 4 weeks of enrollment