RETR(Osteomyelitis)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Osteomyelitis

Treatments: Other: patients having had an osteomyelitis since 2017

Study type: Observational

Funder types: Other

Identifiers

NCT04936958

405

Details and patient eligibility

About

This is a retrospective study describing the management of osteomyelitis in a referece center, with success and failures.

Full description

Chronic osteomyelitis is a serious osteoarticular infection that most often occurs in the long bones (tibia, femur, humerus), responsible for significant morbidity with the risk of fracture and amputation. It is caused by the presence of bacteria in the bone marrow, sometimes responsible for an intraosseous abscess. Chronic osteomyelitis can have a hematogenous or more often exogenous origin, after trauma or surgery.

Despite the progress made in both antibiotics and surgical treatment, the probability of failure of this treatment (infectious recurrence) is of the order of 20%, and has unfortunately remained stable for more than 20 years.

An innovative treatment, Cerament-G (BONESUPPORT AB Laboratory, Sweden), a synthetic bone substitute composed of hydroxyapatite, calcium sulphate, and gentamicin (CE marking), fills the "dead space" which is formed during surgery, prevents this cavity filled with blood from becoming infected, and promotes the regeneration of the bone within this space, limiting the risk of fracture in the medium and long term. It also locally delivers very high doses of gentamicin for several weeks.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who presented with osteomyelitis between 2017 and 2021

Exclusion criteria

• Patients who objected to participating in the study

Trial design

50 participants in 1 patient group

patients having had an osteomyelitis since 2017

Treatment:

Other: patients having had an osteomyelitis since 2017