Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone

Fredericia Hosptial

Status and phase: Unknown; Phase 2

Conditions: Kidney Stone; Ureteroscopy

Treatments: Drug: Isoproterenol

Study type: Interventional

Funder types: Other

Identifiers

NCT00323843

2005-005972-34

Details and patient eligibility

About

Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human to determine its potential of lowering intrarenal pressure.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indication for RIRS procedure
• Age > 18 years
• Normotensive
• Capable of understanding information given

Exclusion criteria

• Previous myocardiac infarct
• Daily use of alpha- og beta- blocking medicine og calcium antagonists
• Use of NSAID the last 2 days
• Stone in the ureter
• Declared
• Known malignant disease in urinary tract
• Bladder disease
• Nephrostomies inserted
• JJ-catheters inserted
• Prisoners
• Pregnant
• Nursing mothers

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)