Retrospective Analysis of Patients With Metastatic Renal Cell Carcinoma Treated With CABOzantinib (CABOGEN)

Gruppo Oncologico Italiano di Ricerca Clinica

Status

Enrolling

Conditions

Metastatic Renal Cell Carcinoma

Treatments

Drug: Cabozantinib

Study type

Observational

Funder types

Other

Industry

Identifiers

NCT06548867

GOIRC-08-2018

Details and patient eligibility

About

CABOGEN is a Observational, retrospective, multicenter study that will enroll patients with metastatic clear cell renal carcinoma (mccRCC) treated with cabozantinib after one or more previous lines of treatment that included TKIs, immune checkpoint inhibitors or mTOR inhibitors.

Full description

The aim of this study is to describe the genomic profiling of patients with metastatic renal cell carcinoma (mRCC) who are long-lasting responders to treatment with cabozantinib and patients who are not long-lasting responders to the cabozantinib treatment.

The study plan to enroll about 80 patients in 10 Italian centers:

Group A: 40 patients defined as long-lasting responders (PFS ≥ 9 months) Group B: 40 patients defined as primary refractories to cabozantinib (PFS ≤ 3 months)

Tissue samples from nephrectomy or from a metastatic site will be used to perform genomic profiling not older than 5 years.Tissue should be formalin-fixed, paraffin-embedded (FFPE).

Genomic profiling will be performed with a hybrid capture-based next-generation sequencing assay (FoundationONE). The sample will be assayed for all coding exons of 324 cancer-related genes plus select introns from 34 genes that are frequently rearranged in cancer. Sequencing will be performed to a mean exon coverage depth of >500X. The resulting sequences will be analyzed for all classes of genomic alteration, including short variant alterations, copy number alterations, and selected gene fusions or rearrangements.

Enrollment

80 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years.
Patients with histological diagnosis of predominantly clear cell carcinoma
Availability of the tumor tissue from the primary tumor and/or a metastatic site for the genomic profiling analysis not older than 5 years.
Evaluable disease according to RECIST criteria v 1.1
Treatment with cabozantinib after one or more previous therapies for mRCC
Patient progressed from the start to cabozantinib therapy within 3 months or after 9 months
Any prognosis group according to the IMDC risk score
Signed informed consent must be obtained for living patients. Patients who died and patient untraceable will be analyzed based on the Authorization no. 9/2016 of the Italian Data Protector Supervisor.

Exclusion criteria

Non-availability of tumor tissue from the primary tumor or a metastatic site for biomarker analysis
Patient progressed between 3 and 9 months from the beginning of treatment with cabozantinib.
Non-availability of clinical information useful to evaluate the IMDC risk group at baseline.