Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing (SIBO)

University of Florida

Status: Completed

Conditions: Small Bowel Bacterial Overgrowth Syndrome (SBBOS); Small Intestinal Bacterial Overgrowth Syndrome (SIBO)

Study type: Observational

Funder types: Other

Identifiers

NCT01324895

406-2010

Details and patient eligibility

About

The objective of this study is to compare the efficacy of prokinetics versus antibiotics versus a combination of antibiotics plus prokinetics in the eradication of Small-Intestinal Bacterial Over-Growth Syndrome (SIBO) in those with and without a positive D-xylose Breath Test.

Hypothesis: Patients with SIBO treated with a combination of prokinetics and in particular octreotide and antibiotics will have reduced recurrence rates of SIBO than either therapy given alone.

Full description

We want to determine whether treatment with prokinetics such as Octreotide, Azithromycin, Erythromycin or Tegaserod alone, versus antibiotics alone, or combination of antibiotics plus prokinetics results in symptomatic improvement in patients with SIBO (defined by a positive D xylose Breath test).

Enrollment: 944 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have had 14 C-D-Xylose Breath test performed in GI Motility Laboratory at the University of Florida

Exclusion criteria

• Those who cannot tolerate 14 C-D-Xylose Breath test for any reason