Retrospective Comparative Study of Routine Lower Neck CT in the Staging and Diagnosis of Lung Cancer Across Two Cohorts

U

University College Hospital Galway

Status

Unknown

Conditions

Supraclavicular Lymphadenopathy
Lung Cancer

Treatments

Diagnostic Test: lower neck CT

Study type

Observational

Funder types

Other

Identifiers

NCT03522090
V1.0

Details and patient eligibility

About

This is a study comparing routine inclusion of the lower neck in initial CT thorax in patients with suspected lung cancer to not including it. The study aims to assess whether such an intervention reduces the number of invasive investigations required to achieve a final diagnosis and clinical stage and whether it improves the detection of cervical lymph nodes involvement by lung cancer.

Full description

Two practices currently exist regarding the role of lower neck CT in patients with suspected lung cancer but with little evidence for either. Routine lower neck CT is potentially associated with benefits of higher detection of neck lymphadenopathy leading to better staging, less invasive procedure with positive implications for patients experience and care. The potential harms are delay in diagnosis due to false positive findings and radiation exposure. There is limited evidence in this area so this study will potentially provide evidence to inform health policy decisions based on the risk benefit balance. This is a retrospective comparative study to assess the real-life impact of routine lower neck CT on the diagnostic and staging work up of patients with suspected lung cancer across two cohorts.

Enrollment

164 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Male or female age > 18 years
  • Pathologically confirmed primary lung cancer
  • Intrathoracic N2 and or N3 disease on CT defined as lymph node with short diameter > 10 mm

Exclusion criteria

  • None

Trial design

164 participants in 2 patient groups

No neck CT
Description:
Cohort of patients with suspected lung cancer where the lower neck is not routinely included in CT
Treatment:
Diagnostic Test: lower neck CT
Neck CT
Description:
Cohort of patients with suspected lung cancer where the lower neck is routinely included in CT
Treatment:
Diagnostic Test: lower neck CT

Trial contacts and locations

0

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Central trial contact

Mohammed Ahmed, Dr

Data sourced from clinicaltrials.gov

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