Retrospective Review of Esophageal Cancer at MSKCC

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Esophagus Cancer; Esophageal Cancer

Treatments: Procedure: Esophagectomy

Study type: Observational

Funder types: Other

Identifiers

NCT05706558

16-1631

Details and patient eligibility

About

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Enrollment: 4,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy
• Pathologic staged T3 tumors (pT3)

Exclusion criteria

• Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)
• Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,
• Patients undergoing salvage esophagectomy
• Evidence of distant metastatic disease
• Patients with a positive proximal or distal margin

Trial design

4,000 participants in 3 patient groups

Circumferential resection margin (CRM)

Description:

Participants will have a diagnosis of esophageal carcinoma and residual tumor \>1 mm from the CRM

Treatment:

Procedure: Esophagectomy

Circumferential resection margin (CRM)-close

Description:

Participants will have a diagnosis of esophageal carcinoma and residual tumor \>0-1 mm from the CRM

Treatment:

Procedure: Esophagectomy

Circumferential resection margin (CRM)+

Description:

Participants will have a diagnosis of esophageal carcinoma and residual tumor at the surgical CRM

Treatment:

Procedure: Esophagectomy