Retrospective Study Assessing Molecular Features Predicting Response to Cetuximab

Istituto Clinico Humanitas

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Genetic: Gene mutations analysis and FISH

Study type: Observational

Funder types: Other

Identifiers

NCT00491140

ICH n. 380

Details and patient eligibility

About

The primary objective is to identify molecular features predicting response or resistance to cetuximab

Full description

Secondary objective is to investigate association of genomic status of EGFR and HER-2 genes with clinical outcome, including objective response, time to progression and survival

Enrollment: 85 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed diagnosis of colorectal cancer with available tumor tissue and clinical data; presence of at least one measurable lesion.

Exclusion criteria

• Less than 3 weeks after completion of previous radiotherapy

Trial design

85 participants in 1 patient group

Observation

Description:

Colorectal cancer patients

Treatment:

Genetic: Gene mutations analysis and FISH