Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients

National Institute of Cardiovascular Diseases, Pakistan

Status and phase

Not yet enrolling

Phase 4

Conditions

Inferior Wall Myocardial Infarction

Complete Heart Block

Treatments

Drug: Aminophylline Injection

Study type

Interventional

Funder types

Other

Identifiers

NCT05666219

ERC-32/2022

Details and patient eligibility

About

In this study we will evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall myocardial infarction (MI)

Full description

Administration of Aminophylline can result in reversal of complete heart block in a significant number of atropine resistant patients with inferior wall MI. Hence, in this study our primary aim is to evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall MI.

Enrollment

73 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patients admitted with recent acute inferior wall myocardial infarction (MI)
Hemodynamically stable blood pressure
Complete heart block with Narrow QRS < 120 ms and ventricular rate >40/min persisting for at least 6 hours resistant to atropine
Temporary pacemaker (TPM) already placed
Patient asymptomatic with mean arterial pressure of greater than 65 mmHg with TPM rate placed at 40/min

Exclusion criteria

Patients with cardiogenic shock
Patients with preexisting permanent pacemaker and Implantable Cardioverter Defibrillator (ICD).
Patients with prior history of AV block
Drugs with dromo-tropic effects (beta blocker, calcium channel blocker, inotropes)
Known liver disease (cirrhosis, hepatitis)
Hypothyroidism
Unable to consent