Reversal of General Anesthesia With Methylphenidate

Mass General Brigham

Status and phase: Completed; Phase 2; Phase 1

Conditions: Emergence From Anesthesia; Post Operative Cognitive Dysfunction

Treatments: Other: Saline; Drug: Methylphenidate

Study type: Interventional

Funder types: Other

Identifiers

NCT02051452

2013P001114

Details and patient eligibility

About

The aim of this study is to investigate whether methylphenidate (Ritalin) can actively induce emergence from general anesthesia in patients having a pancreaticoduodenectomy (Whipple procedure), a pancreatectomy, or a prostatectomy.

Enrollment: 32 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-75 years
• American Society of Anesthesiologists classification 1 or 2
• Scheduled to undergo a pancreaticoduodenectomy or distal pancreatectomy at Massachusetts General Hospital

Exclusion criteria

• American Society of Anesthesiologists physical status classification of 3 or beyond.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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32 participants in 2 patient groups, including a placebo group

Methylphenidate

Experimental group

Description:

Methylphenidate

Treatment:

Drug: Methylphenidate

placebo

Placebo Comparator group

Description:

Saline

Treatment:

Other: Saline