Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy (RER-CRT)

Johns Hopkins University

Status: Completed

Conditions: Heart Failure; Patients Undergoing CRT-D Device Implantation

Study type: Observational

Funder types: Other

Identifiers

NCT01924221

NA_00065477

Details and patient eligibility

About

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Enrollment: 31 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing implantation of a CRT-D

Exclusion criteria

• age < 18 y
• pregnancy or planned pregnancy

Trial design

31 participants in 1 patient group

CRT

Description:

Patients with implanted cardiac resynchronization therapy defibrillator