Reverse Prediction of Ion Channel Remodeling in Patients With Atrial Fibrillation Utilizing Monophasic Action Potential and Mathematical Modeling

Yonsei University

Status: Completed

Conditions: Atrial Fibrillation

Treatments: Device: Monophasic action potential(MAP) catheter

Study type: Interventional

Funder types: Other

Identifiers

NCT02414815

4-2014-0685

Details and patient eligibility

About

Atrial fibrillation(AF) is the most common sustained arrhythmia in humans. The loss of rate-dependent action potential duration(APD) adaptation is one of the characteristics of atrial fibrillation, but detailed understanding of mechanism is limited. Thus, we propose to utilize the monophasic action potential recording data from human patients in three groups, control, paroxysmal and persistent atrial fibrillation, and apply reverse engineering method to quantify the extent of electrical remodeling of ionic channel parameters using a mathematical model of atrial cell. Our approach will be useful in developing drug targets for ion channels in atrial fibrillation patients.

Enrollment: 50 patients

Sex: All

Ages: 19 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients agreement of consent
• AF patient age 19-75
• Patients who undergoing catheter ablation of atrial fibrillation or supraventricular tachycardia
• Patient agreement of consent who admission for catheter ablation

Exclusion criteria

• Patients who do not agree with study inclusion
• Permanent AF refractory to electrical cardioversion
• AF with rheumatic valvular disease
• Patients with left atrial diameter greater than 60mm
• Patients with age less than 19 or more 75

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

AF group

Experimental group

Description:

Atrial fibrillation

Treatment:

Device: Monophasic action potential(MAP) catheter