Reversibility of Diastolic Disfunction in Septic Shock (REPRISS)

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Unknown

Conditions: Diastolic Dysfunction; Septic Shock

Treatments: Diagnostic Test: Echocardiography

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT03198611

IIBSP-REP-2017-30

Details and patient eligibility

About

Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality at 90 days.

2.4. Secondary objectives: A) Incidence and reversibility of myocardial dysfunction (left ventricular systolic and diastolic) in septic shock.

B) Incidence and reversibility of diastolic dysfunction according to the echocardiographic criterion used.

C) Incidence and reversibility of right ventricular systolic dysfunction.

Enrollment: 350 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted to the ICU with diagnosis of septic shock, and stay longer than 48h

Exclusion criteria

• No echocardiographic window
• Fatal prognosis with do not resuscitate orders at admission
• Previous history of Ischemic cardiomyopathy
• Valvular prosthesis
• Advanced degree of valvular disorder
• Advanced degree of pericardial effusion

Trial design

350 participants in 4 patient groups

Normal function

Description:

No systolic dysfunction No diastolic dysfunction No right ventricular dysfunction

Treatment:

Diagnostic Test: Echocardiography

Left ventricular systolic dysfunction

Description:

Left ventricular ejection fraction \< 50%

Treatment:

Diagnostic Test: Echocardiography

Left ventricular diastolic dysfunction

Description:

Classification according to: * Mitral lateral annulus e' in tissue Doppler \< 10 cm/s * American society of echocardiography (ASE) criteria 2009 * ASE criteria 2016

Treatment:

Diagnostic Test: Echocardiography

Right ventricular dysfunction

Description:

Tricuspid annulus plane systolic excursion \< 17 cm

Treatment:

Diagnostic Test: Echocardiography