Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation

A

Ain Shams University

Status

Completed

Conditions

Minimal Hepatic Encephalopathy

Treatments

Procedure: Liver transplantation

Study type

Observational

Funder types

Other

Identifiers

NCT02767622
875

Details and patient eligibility

About

This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls before and 6 months after liver transplantation. Assessment of cognitive functions by Trail Making Test A (TMT A), TMT B, Digit Symbol Test (DST), and Serial Dotting Test (SDT) was done before and after liver transplantation.

Enrollment

40 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation

Exclusion criteria

  • Overt hepatic encephalopathy.
  • Significant cortical atrophy or other structural brain changes revealed by conventional neuro-imaging.
  • Regular use of psychotropic drugs, such as benzodiazepines.
  • Known major psychiatric disorder.
  • Less than 6 months of complete alcohol abstinence.
  • Post-transplant toxic levels of immunosuppressive drugs.
  • Patients unable to perform the tests (Illiterate or upper limb motor handicaps).

Trial design

40 participants in 2 patient groups

Patient Group
Description:
Twenty right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation.
Treatment:
Procedure: Liver transplantation
Control Group
Description:
Twenty age-matched healthy persons. They were similar to the patient group in respect to the number of education years, sex, and handedness.

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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