Review of Human Herpes Viruses in Burns

The University of Texas System (UT)

Status: Completed

Conditions: Herpes Simplex Virus; Human Herpes Virus; Cytomegalovirus; Burns; Chickenpox; Varicella-zoster Virus

Treatments: Other: Review of the Literature for Human Herpes Virus infections

Study type: Observational

Funder types: Other

Identifiers

NCT02452229

SHC-G-SR-HHV

Details and patient eligibility

About

Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Full description

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.

Enrollment: 10,267 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who presented with at least 1% TBSA burned
• Patients who presented with a viral infections during their hospitalization

Exclusion criteria

• Patients who had no burns
• Patients who had no viral infections during their hospitalization

Trial design

10,267 participants in 1 patient group

Burn patients

Description:

The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.

Treatment:

Other: Review of the Literature for Human Herpes Virus infections