Reward and Punishment Sensitivity in Bipolar Disorders (Recodec-BP)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Bipolar Disorder

Treatments: Behavioral: behavioral assessment

Study type: Observational

Funder types: Other

Identifiers

NCT04237610

38RC18.171

2018-A01962-53 (Other Identifier)

Details and patient eligibility

About

Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical settings. Whereas distinguishing BD-I and BD-II main subtypes has a significant relevance for treatment strategy and for outcome, there are currently no clinical determinants of the BD subtype which could be used as early diagnostic predictors.

• While neurobiological specificity of each BD subtype is still controversial, available evidence suggest different dopaminergic abnormalities in each subtype. Dopaminergic function is involved in decision making and reward processing which may represent useful BD subtype markers.
• This study aims at assessing decision making during appetitive and punitive reinforcement learning in patients with BD I and BD II subtypes compared to healthy controls

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• bipolar disorder (BD) type I or II, according to DSM (Diagnostic and Statistical Manual)-5 criteria
• Montgomery and Asberg Depression Rating Scale (MADRS) score < 15
• Young Mania Rating Scale (YMRS) score < 12

Exclusion criteria

• other main diagnosis than bipolar disorder
• other medical condition leading to cognitive deterioration

Trial design

90 participants in 3 patient groups

Bipolar disorder type I

Treatment:

Behavioral: behavioral assessment

Bipolar disorder type II

Treatment:

Behavioral: behavioral assessment

healthy controls

Treatment:

Behavioral: behavioral assessment