RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects

SVS Institute of Dental Sciences

Status and phase: Unknown; Phase 1

Conditions: Periodontitis

Treatments: Drug: Plain Collagen; Drug: RhEGF

Study type: Interventional

Funder types: Other

Identifiers

NCT04375618

SVSIDS/perio/5/2019

Details and patient eligibility

About

A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla. At the recession sites rhEGF incorporated absorbable collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.

Full description

IN TEST SITE :

Local anesthesia will be administered and Vertical incisions will be given at interdental papillae away from recession defect site and a pouch will be created. A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla. At the recession sites rhEGF incorporated absorbable collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.

IN CONTROL SITE:

Same procedure will be done as the test site but plain collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Systemically healthy male and female patients of age 20-55 yrs with Millers class I or class II gingival recession are included in the study.

Exclusion criteria

• Patients who are medically compromised and Subjects who underwent radiotherapy or chemotherapy and who are Smokers are excluded from the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

EGF impregnated in collagen membrane

Experimental group

Description:

EGF impregnated in collagen membrane is placed in gingival recession defects

Treatment:

Drug: RhEGF

plain collagen membrane

Active Comparator group

Description:

plain collagen membrane is placed in gingival recession defects

Treatment:

Drug: Plain Collagen